St. Luke’s Medical Center is recognized as the leading and most respected healthcare institution in the Philippines. Its two facilities in Quezon City and Global City, Taguig are at par with the most advanced hospitals around the world. A testament to St. Luke's world class quality medical service is its accreditation with, and affiliation to, prestigious international organizations.

St. Luke’s - Quezon City has the sole distinction of being the first hospital in the country accredited by the JCI, or Joint Commission International: the international arm of the Joint Commission on Accreditation of Healthcare Organizations (JCAHO)—the oldest and most prestigious healthcare accreditation organization in the world—which the facility received in 2003. It is also only the second hospital in Asia to be JCI-accredited. In 2016, it was also the first in the country to be accredited by JCI as an Academic Medical Center Hospital. St. Luke’s - Global City, on the other hand, earned its ownJCI hospital accreditation in 2012 after only two years of operation. Both hospitals are also accredited by JCI for the Clinical Care Program Certification (CCPC) for the Primary Stroke Program.